PSV vs Napoli Prediction (21/10/25) Champions League Betting Tips & Odds

PSV vs Napoli
20:00 • Tue 21 Oct • Philips Stadion

Predicted Score
1-3
Napoli Win

Myriadplay
2.15
BET

Bet442
2.15
BET

NRGbet
2.15
BET

Odds shown are for illustration purposes only and are not live. Please check bookmaker sites for current odds. 18+
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Our Prediction Eindhoven for PSV vs Napoli

Napoli travel to the Philips Stadion to face PSV Eindhoven on Tuesday night, with both sides eager to strengthen their positions in the Champions League standings. PSV have impressed under Peter Bosz, but Antonio Conte’s Napoli possess the tactical discipline and attacking firepower to take all three points.
Prediction Napoli to win 3–1

PSV vs Napoli Champions League Prediction

PSV Eindhoven Form Analysis

PSV Eindhoven remain unbeaten at home this season and continue to play some of the most fluid football in Europe. Peter Bosz has moulded his side into a dynamic attacking unit, driven by the creativity of Ismael Saibari and the control of Joey Veerman in midfield. Couhaib Driouech’s pace on the left adds width and unpredictability, while Guus Til’s late runs into the box make PSV a constant goal threat.

Despite their attacking flair, PSV’s defensive record remains fragile, having conceded in four of their last five fixtures. The Dutch champions will need to maintain focus against a Napoli side known for their quick transitions and ruthless finishing.

Injuries None reported for PSV

Napoli Form Analysis

Napoli enter this fixture on the back of a 2–1 victory over Genoa, a result that steadied their domestic form and boosted confidence in Europe. Antonio Conte’s side have been hit by injuries but remain competitive, with Rasmus Højlund continuing to impress as the focal point of attack.

The midfield is anchored by Stanislav Lobotka, whose calm distribution and spatial awareness allow André-Frank Zambo Anguissa to push forward and connect play between the lines. Scott McTominay adds energy and directness, while David Neres’s trickery out wide ensures Napoli retain an attacking edge even without Romelu Lukaku or Matteo Politano.

Injuries Nikita Contini, Amir Rrahmani, Alessandro Buongiorno, Stanislav Lobotka, Romelu Lukaku, and Matteo Politano remain sidelined

Best Betting Odds for PSV Eindhoven vs Napoli

Market NRGbet Bet442 Myriadplay
Napoli to Win 2.15 2.15 2.15
Draw 3.60 3.75 3.60
PSV to Win 3.00 3.00 3.00
Over 2.5 Goals 1.60 1.65 1.60
Both Teams to Score 1.50 1.53 1.50

The Champions League betting odds suggest a tight encounter, though Napoli are slight favourites given their superior experience at this level. Over 2.5 goals looks the strongest value bet, with both teams boasting plenty of attacking options.

Last Encounters Between PSV Eindhoven and Napoli

These sides last met in the 2012 Europa League group stage, producing two entertaining fixtures. PSV dominated at home before Napoli responded in the return match.

04/10/2012 PSV 3–1 Napoli (Europa League Group Stage)
06/12/2012 Napoli 2–1 PSV (Europa League Group Stage)
PSV won 4–3 on aggregate

Probable Lineups for PSV Eindhoven vs Napoli

PSV Predicted Lineup (4-2-3-1)

GK Matej Kovar
RB Sergiño Dest CB Jerdy Schouten CB Yarek Gasiorowski LB Anass Salah-Eddine
CM Mauro Júnior CM Joey Veerman
RW Dennis Man CAM Ismael Saibari LW Couhaib Driouech
ST Guus Til

Coach: Peter Bosz

Injuries: None reported for PSV

Napoli Predicted Lineup (4-1-4-1)

GK Vanja Milinković-Savić
RB Giovanni Di Lorenzo CB Sam Beukema CB Juan Jesus LB Mathías Olivera
CDM Stanislav Lobotka
RM David Neres CM Scott McTominay CM André-Frank Zambo Anguissa LM Matteo Politano
ST Rasmus Højlund

Coach: Antonio Conte

Injuries: Nikita Contini, Amir Rrahmani, Alessandro Buongiorno, Stanislav Lobotka, Romelu Lukaku, and Matteo Politano remain sidelined

Where to Watch PSV Eindhoven vs Napoli

UK viewers can watch the Champions League action live on TNT Sports, with coverage beginning ahead of the 20:00 BST kick-off on Tuesday 21 October 2025.

Players That Used to Play in the EFL

Sam Beukema – Formerly Sheffield Wednesday (Championship)
Beukema gained valuable experience during his time in the EFL Championship with Sheffield Wednesday, adapting to the league’s physicality and direct style. That stint has influenced his composure and defensive awareness, qualities that now make him a reliable presence in Napoli’s back line.

Lewis is a football and sports betting expert from the UK. He closely follows the English Premier League and EFL, along with other major competitions from across the globe. He has written extensive analysis and football match predictions, covering tournaments such as the EPL and FIFA World Cup

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