Monaco vs Tottenham Hotspur Prediction (22/10/25) Champions League Betting Tips & Odds

Monaco vs Tottenham Hotspur
20:00 • Tue 22 Oct • Stade Louis II
Predicted Score
2-3
Tottenham Win
Myriadplay
2.90
BET
NRGbet
2.40
BET
Bet442
2.35
BET
Odds shown are for illustration purposes only and are not live. Please check bookmaker sites for current odds. 18+
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Our Prediction for Monaco vs Tottenham

Tottenham Hotspur travel to the Stade Louis II for a key Champions League fixture that could shape their league-phase campaign. Monaco, still seeking their first win in Europe this season, face a confident Spurs side under Thomas Frank.

Tottenham arrive following a 2–1 win over Leeds and remain unbeaten in continental competition. Monaco have drawn their last two matches against Nice and Manchester City but remain inconsistent defensively. With both sides committed to attacking football, this promises to be an open and high-tempo contest. Spurs’ organisation and sharp finishing should prove decisive.

AS Monaco Form Analysis

Monaco approach this clash under pressure after a mixed start to their Champions League league-phase campaign. They have scored in every fixture but conceded six goals in two European games, exposing the lack of balance in their back line. Injuries to Aleksandr Golovin, Vanderson and Paul Pogba have weakened both creativity and control.

Ansu Fati and Maghnes Akliouche have provided attacking flair, while Folarin Balogun’s energy and direct runs continue to trouble defences. Adi Hütter’s side often switch between a 4-2-3-1 and a 3-4-2-1, but defensive transitions remain their Achilles heel. Without Golovin’s rhythm in midfield, Monaco rely heavily on wide play and quick counters which is a risky approach against a compact Tottenham side.

Monaco vs Tottenham Hotspur Prediction (22/10/25) Champions League Betting Odds

Tottenham Hotspur Form Analysis

Tottenham continue to impress under Thomas Frank, combining structure with attacking purpose. Their recent win at Leeds followed a strong showing against Villarreal and extended their unbeaten European run. Spurs’ Champions League predictions this week centre on their midfield trio, where João Palhinha provides stability behind the creative pairing of Xavi Simons and Mohammed Kudus.

Injuries persist, with James Maddison, Radu Drăgușin and Dominic Solanke all sidelined. Still, Micky van de Ven and Cristian Romero have formed a reliable partnership, while Pedro Porro and Destiny Udogie stretch play from the flanks. Richarlison’s return to scoring form has restored confidence up front and given Tottenham’s attack a sharper edge.

Best Betting Odds for Monaco vs Tottenham

Outcome NRGbet Bet442 Myriadplay
Tottenham to Win 2.40 2.35 2.90
Draw 3.60 3.50 3.50
Monaco to Win 2.70 2.70 2.70
Over 2.5 Goals 1.62 1.58 1.58
Both Teams to Score 1.53 1.48 1.48

Tottenham are narrow favourites in the latest Champions League odds, reflecting their stronger form and superior attacking balance. Champions League betting predictions point to an open contest with goals for both sides. Among this week’s Champions League tips, over 2.5 goals appears the standout selection.

Last Encounters Between Monaco and Tottenham

25/11/2016: Monaco 2–1 Tottenham Hotspur (UEFA Champions League Group Stage)
14/09/2016: Tottenham Hotspur 1–2 Monaco (UEFA Champions League Group Stage)

AS Monaco vs Tottenham Hotspur Predicted Lineup

AS Monaco (4-2-3-1)

GK Philipp Köhn
RB Thilo Kehrer CB Mohammed Salisu CB Eric Dier LB Caio Henrique
CM Mamadou Coulibaly CM Takumi Minamino
RW Maghnes Akliouche CAM Ansu Fati LW Krépin Diatta
ST Folarin Balogun

Injured / Suspended: Aleksandr Golovin (out), Paul Pogba (out), Christian Mawissa (out), Vanderson (out), Lukas Hrádecký (out)
Coach: Adi Hütter

Tottenham Hotspur (4-3-3)

GK Guglielmo Vicario
RB Pedro Porro CB Micky van de Ven CB Cristian Romero LB Destiny Udogie
CM João Palhinha CM Xavi Simons CM Mohammed Kudus
RW Brennan Johnson ST Richarlison LW Wilson Odobert

Injured / Suspended: Cristian Romero (out), James Maddison (out), Radu Drăgușin (out), Dominic Solanke (out), Kolo Muani(out), D. Kulusevski(out)
Coach: Thomas Frank

Where to Watch Monaco vs Tottenham

Fans in the UK can watch this match live on TNT Sports, with kick-off at 20:00 BST on Wednesday 22 October.

Players That Used to Play in the EFL

Folarin Balogun – Formerly Middlesbrough (loan)
Balogun’s loan spell in the Championship with Middlesbrough was key to his development. It strengthened his physicality and decision-making in tight spaces, traits that have carried over into his Champions League performances for Monaco.

Lewis is a football and sports betting expert from the UK. He closely follows the English Premier League and EFL, along with other major competitions from across the globe. He has written extensive analysis and football match predictions, covering tournaments such as the EPL and FIFA World Cup

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